Research Interests: Biochemistry/Chemical Toxicology. The main interest of our group is to study the combination effect of light and various industrial and environmental chemicals on human health. Some of the research areas include photochemical reaction mechansim, degradation technology development, DNA interaction and damage, photomutagenity, and photocytotoxicity/photogenotoxicity study. Those environmental and industrial chemicals covered are: Polycyclic aromatic hydrocarbons (PAH), polychlorobiphenyls (PCB), Polybromodiphenylether (PBDE), Cosmetic chemicals (azulene), and pharmaceuticals (tamoxifen), etc. Publications (last three years): 1. Yan, J.; Wang, L.; Fu, P.; Yu, H. "Photomutagenicity of sixteen polycyclic aromatic hydrocarbons from the US EPA's priority pollutant list", Mutat. Res., 557(1), 99-108, 2004. 2. Zeng, K.; Hwang, H.; Dong, S.; Shi, X.; Wilson, K.; Green, J.; Jiao, Y.; Yu, H. "Photochemistry and Phototoxicity of 1-aminopyrene", Environ. Toxicol. Chem., 23(6), 1400-1407, 2004. 3. Hwang, H.; Balarezo, A. L.; Jones, V. N.; Yu. H. “Effect of river humic acid on 1-aminopyrene ecotoxicity in a dynamic solar photolysis process”, Bull. Environ. Contam. Toxicol., 72 (5), 1059-1066, 2004. 4. Wang, L; Yan, J.;
Cohly, H.; Hwang, H.-M.; Wang, S.; Fu, P.; Yu, H. “Photo-Acute Toxicity
and Genotoxicity of Azulene on Human Jurkat T-Cells”, Mutat. Res.,
562 (1-2), 143-150, 2004. 8. Wang, L.; Yan, J.; Fu, P. P.; Parekh, K.; Yu, H. “Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene”, Mutat. Res.,, 530(1/2), 19-26, 2003. 9. Zeng, K., Hwang, H.-M., Zhang, Y., Yu, H. “Identification of 6-aminochrysene photoproducts and study of the effect of a humic acid and riboflavin on its photolysis”, J. Photochem. Photobiol. B, 72, 95-100, 2003. 10. "Recent advances
in environmental health research: Health disparities, toxicology and carcinogenesis",
Paul Tchounwou, and Hongtao Yu, Editors, MDPI, Basel, Switzerland, 2003 12. Dong, S.; Fu, P. P.; Shirsat, R. N.; Hwang, H.-M.; Leszczynski, J.; Yu, H. “UVA Light-Induced DNA Cleavage by Isomeric Methylbenz[a]anthracenes”, Chem. Res. Toxicol., 15, 400-409, 2002. 13. Jiao, Y.; Valente, E.; Garner, S.; Wang, X.; Yu, H. “Unexpected thermal rearrangement of N-alkoxycarbonyl imidazole acryl azides to imidazo[1,5-c]pyrimidinone or imidazo[4,5-c]pyridinone” Tetrahedron Lett. 43(33), 5879-5881, 2002. 14. Jiao, Y.; Stringfellow, S.; Yu, H. “Distinguishing ‘looped-out’ and ‘stacked-in’ DNA bulge conformations using fluorescent 2-aminopurine replacing a purine base”, J. Biomol. Struct. Dyn., 19(5), 929-934, 2002. 15. Wang, K.; Stringfellow, S.; Dong, S.; Jiao, Y.; Yu, H. “Synthesis and Fluorescence Study of 7-Azaindole in DNA Oligonucleotides replacing a Purine Base”, Spectrochim. Acta A: Mol. & Biomol. Spec., 58(12), 2595-2603, 2002. 16. Yu, H.; Dong, S.; Fu, P. P.; and Hwang, H.-M. “UVA Light-Induced DNA Single Strand Cleavage by Hydroxybenzo[a]pyrenes”, J. Polycycl. Arom. Compd., 22 (3-4), 861-870, 2002. 17. Hwang, H.-M.; Zeng, K.; Dong, S.; and Yu, H. “A study of photoinduced toxicity of 1-aminopyrene to microbial assemblages and the effect of humic substance on 1-aminopyrene photolysis”, J. Polycycl. Arom. Compd., 22(3-4), 611-620, 2002. 18. Dong, S.; Fu, P. P.; Hwang, H.-M.; and Yu, H. “Effects of Histidine on Light-Induced DNA Single Strand Cleavage by Selected Polycyclic Aromatic Hydrocarbons”, J. Polycycl. Arom. Compd., 22(3-4), 451-458, 2002. 19. Zeng, K.; Hwang, H.-M.; Fu, P. P.; Yu, H. “Identification of 1-hydroxypyrene Photoproducts and Study of the Effect by Humic Substances on Its Photolysis”, J. Polycycl. Arom. Compd., 22(3-4), 459-467, 2002. 20. Wu, Y.; Fang, G.; Moody, J.; Fu, P. P.; Hwang, H. and Yu, H. "In Vitro Metabolism of Dibenzo[a,l] pyrene, 2-Chlorodibenzo[a,l]pyrene and 10-Chlorodibenzo[a,l]pyrene - Effects of Chloro Substitution", Int. J. Mol. Sci., 3, 1008-1018, 2002. 21. K. Zeng, H. Hwang, H. Yu, "The Effect of Dissolved Humic Substances on the Photochemical Degradation Rate of 1-Aminopyrene and Atrazine", Int. J. Mol. Sci., 3, 1048-1057, 2002. 22. S. Dong, S. Wang, G. Stewart, H. Hwang, and H. Yu, "Effect of solvents and biologically relevant ions on the light-induced DNA cleavage by polycyclic aromatic hydrocarbons", Int. J. Mol. Sci., 3, 937-947, 2002. 23. Balarezo, A. L., Jones, V. N., Yu, H., Hwang, H.-M. “Influence of Humic Acid on 1-Aminopyrene Ecotoxicity during Solar Photolysis Process”, Int. J. Mol. Sci., 3, 1133-1144, 2002. 24. Cui, H.; Hwang, H.-M.; Zeng, K.; Glover, H.; Yu, H.; and Liu, Y. “Riboflavin-photosensitized degradation of atrazine in a freshwater environment”, Chemosphere, 47(9), 991-9, 2002. Papers Presented (last
three years) 2. S. Wang, H. Yu, L. Wang, J. Yan, “Photocytotoxicity of 16 polycyclic aromatic hydrocarbons from the US EPA priority pollutant list in Jurkat T-cells”, 32nd Annual Meeting of the American Society for Photobiology, Seattle, WA, P65, July 10-14, 2004. 3. J. Yan, S. Cherng, Q. Xia, W. G. Wamer, J. R. Bucher, P. C. Howard, H. Yu, P. P. Fu, “Photoclastogenicity of retinyl palmitate and its photodecomposition products”, 32nd Annual Meeting of the American Society for Photobiology, Seattle, WA, P51, July 10-14, 2004. 4. G. Stewart, J. Yan, L. Wang, and H. Yu, “Photochemical Degredataion of nitro polycyclic aromatic hydrocarbons”, Mississippi Academy of Sciences 68th annual meeting, February 19-20, 2004, Biloxi, MS. 5. W. Hardy, C. Mosley, L. Wang, J. Yan, and H. Yu, “Photomutagenicity of a hair dye ingredient 3,3’-dichlorobenzidine (DCB)”, Mississippi Academy of Sciences 68th annual meeting, February 19-20, 2004, Biloxi, MS. 6. L. Wang, C. Mosley, W. Hardy, J. Yan, H. Cohly, S. Wang, H. Yu, “Light-induced cytotoxicity and genotoxicity of 3,3’-dichlorobenzidine (DCB)”, 14th International Congress on Photobiology, June 10-15, 2004, Jeju, Korea. 7. Xu, J., Yu, H. Photochemical reaction of chrysene in acetonitrile/water, 19th ISPAC Meeting, September 21-25, 2003, Amsterdam, Holland. 8. Yu, H., Hwang,
H.-M., Zeng, K., Shi, X., Photochemistry and phototoxicity of 1-aminopyrene,
10th Congress for the European Society for Photobiology, September 6-11,
2003, Vienna, Austria. 10. Zeng, K., Hwang, H., Yu, H. “Photosensitized Photolysis of 6-aminochrysene (6AC) by humic acid and riboflavin”, Abstract page 71, Pittcon 2003, March 9-13, 2003, Orlando, FL. 11. Yu, H., Yan, J.,
Wang, L., Fu, P. P., “Photomutagenicity of ten priority polycyclic
aromatic hydrocarbons (PAHs)”, pp 46, The 31st American Society
for Photobiology Meeting, July 5-9, 2003, Baltimore, MD. 13. DeMarcio Reed, “Photochemistry of selected nitro-polycyclic aromatic hydrocarbons”, Mississippi Academy of Sciences, February 13-14, Hattiesburg, MS, 2003. 14. DeMarcio Reed, “Photochemistry of selected nitro-polycyclic aromatic hydrocarbons”, Alliance for Graduate Education, January 24-25, Starkville, MS, 2003. 15. H. Yu, “Photochemistry of Polycyclic Aromatic Hydrocarbons”, California State University, Fullerton, December 12, 2002. 16. L. Wang, H. Cohly, B. Graham Evans, J. Yan, H. Hwang, H. Yu, “Toxic Effects of Azulene and Light on Skin Elements”, Eighth RCMI International Symposium on Health Disparities, Honolulu, Hawaii, December 8-11, 2002. 17. H. Cohly, J. Yan, L. Wang, H. Hwang, H. Yu, “Toxic Effects of Selected Polycyclic Aromatic Hydrocarbons and Light on Skin Cells”, Eighth RCMI International Symposium on Health Disparities, Honolulu, Hawaii, December 8-11, 2002. 18. H. Hwang, A. Belazero, V. Jones, H. Yu, “Use of Microbial Assay to Assess the Effect of Humic Acid on 1-Aminopyrene Ecotoxicity during Solar Photolysis Process”, Eighth RCMI International Symposium on Health Disparities, Honolulu, Hawaii, December 8-11, 2002. 19. H. Yu, “Photochemistry and Phototoxicity of Polycyclic Aromatic Hydrocarbons”, University of Mississippi Medical Center, Jackson, October 3, 2002. 20. H. Yu, “Photochemistry and Phototoxicity of Polycyclic Aromatic Hydrocarbons”, East Tennessee State University, Johnson City, August 30, 2002. 21. Yu, H. “Light-Induced Reactions of Environmental and Cosmetic Chemicals with DNA”, International Symposium on Frontiers of Molecular Sciences, Qingdao, China, July 14-19, 2002. 22. Yu, H. “Light-Induced Reactions of Environmental and Cosmetic Chemicals with DNA”, Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing, China, July 9, 2002. 23. Yu, H. “Phototoxicity of environmental chemicals”, SETAC Meeting, Vicksburg, MS, June 2-3, 2002. 24. Stewart, G., Dong, S., Yu, H. “Effect of biologically relevant ions on the light-induced dna cleavage by polycyclic aromatic hydrocarbons”, 2002 RCMI Symposium, Jackson, MS, April 24-27, 2002. 25. Wang, S., Dong, S., Hwang, H-M., Fu, P. P., Yu, H. “Solvent effect on the light-induced DNA cleavage by selected polycyclic aromatic hydrocarbons”, 2002 RCMI Symposium, Jackson, MS, April 24-27, 2002. 26. Moncrief, A., Jiao, Y., Dong, S., Hwang, H., Fu, P. P., Yu, H. “Study of the photochemical degradation of nitro-substituted polycyclic aromatic hydrocarbons and light-induced damages to DNA”, 2002 RCMI Symposium, Jackson, MS, April 24-27, 2002. 27. Zeng, K., Dong, S., Hwang, H., Yu, H. “Study of photochemical transformation of 1-aminopyrene and light-induced DNA damages”, 2002 RCMI Symposium, Jackson, MS, April 24-27, 2002. 28. Balarezo, A. L.,
Jones, V. N., Hamadain, E. H. Yu, Hwang, H., “Influence of humic
acid on 1-aminopyrene ecotoxicity during solar photolysis process”,
2002 RCMI Symposium, Jackson, MS, April 24-27, 2002. |
