Faculty Information return to previous page

Ernest B. Izevbigie, Ph.D.

Room # 440, John A. Peoples Science Building

Title Associate Professor of Biology

 

OFFICE HOURS 

 

MON -  10.00 AM    to 12.00 NOON

      or by appointment

 
PHONE  601-979-3464
FAX 601-979-5853
Email ernest.b.izevbigie@ccaix.jsum.edu

 

EDUCATION

 
1986  

Tennessee State University, Nashville, Tennessee, B.Sc with distinction (Animal Science)
1988 The University of Tennessee, Knoxville, Tennessee, M.Sc (Animal Science/Nutrition)
1996 Michigan State University, E. Lansing, Michigan, Ph.D. (Growth/Cellular Biology)
1996-1998 Children's National Medical Center, Washington, DC, Post-doctoral Fellow (Renal Physiology)
1996-1998

National Institute for Dental &Craniofacial Research (NIDCR)/NIH, Bethesda, Maryland Post-doctoral Fellow (Biochemistry/ Cancer Biology).  

             

             

RESEARCH FOCUS AND INTERESTS

The laboratory of Phytoceuticals, Cancer Prevention and Therapies- Our long-term research goal is to characterize mechanisms involved in tumorigenesis and to develop novel phytochemotherapies for the treatment and/or prevention of cancer; the development and therapeutic index assessment of novel plant-derived agents as candidates for breast cancer prevention and/or therapies. Molecular, Biochemical, and cell biological experimental strategies and mouse xenograft model are also utilized for screening potential drug candidates.

Patents

  • A novel method for producing cyclic 3’-5’ Adenosine Monophosphate Extracellularly

    • (Pat # 6541196)

  • A novel Phytochemotherapeutic agent for breast cancer (Patent # 6,713,098)

  • A novel Phytochemotherapy (Edotides) for breast cancer (Patent #6,849,604)

Publications
 

Cain ML, Hester RL, Izevbigie EB. Ethanol Abrogates Angiotensin II-Stimulated Vascular Smooth Muscle Cell Growth, Medical Sci. Monit.  (in press), 2005.

 

Opata M, Izevbigie EB. Aqueous V. amygdalina extracts alters MCF-7 cell membrane permeability and efflux. Under revision, 2005.

 

Izevbgie, EB.  Signaling pathways in human breast cancers in response to alcohol: mechanisms for alcohol-induced breast cancer. Comprehensive handbook of alcohol related pathology volume 2 (chapter 79), London, Elsevier, 2005.

 

Izevbigie EB, Bryant JL, Walker A. A natural Inhibitor of extracellular signal-regulated kinases and   human breast cancer cells. Exp. Biol.  Med. 229: 163-169, 2004.

 

Izevbigie EB. Discovery of water-soluble anticancer agents from a vegetable found in Benin City, Nigeria. Exp. Biol.  Med. 228(3): 293- 298, 2003.

 

Ventura-Holman T, Lu D, Si X, Izevbigie EB, Maher JF. The Fem1c Genes: Conserved  members of the Fem1 gene family in vertebrates. Gene 314: 133-139, 2003.

 

Howard CB, Stevens J, Izevbigie EB, Walker A, McDaniel O. Time and dose-dependent modulation of phase 1 and phase 2 gene expression in response to treatment of MCF-7 cells with a natural anticancer agent.  J.  Cell.  Mol. Biol. 49(7): 1057-1065, 2003.

 

Izevbigie, EB, Bryant, JL, Walker, A. Edible Vernonia amygdalina leaf extracts Inhibit Extracellular Signal-regulated kinases and Human Breast Cancer Cell growth. J. Nutr. 133(11): 3860S, 2003.

 

Izevbigie, E.B., Ekunwe, S.I., and Howard, CB. Ethanol modulates the growth of human breast  cancer cells in vitro.  Exp. Biol.  Med. 227(4): 260-265, 2002.

Izevbigie, E.B., Gutkind, J.S., and Ray, P.E. Angiotensin II and  fibroblast growth factor-   2 modulate the proliferation of human fetal mesangial  cells through different signaling mechanisms. Pediatric Research 47(5): 614- 621, 2000.

 

Izevbigie, E.B., Bergen, W.G. b-adrenergic agonist  hyperplastic effect is  Associated with increased fibronectin geneexpression not mitogen-activated protein Kinase Modulation in C2C12 myoblasts. Exp. Biol. Med 223: 302-309, 2000.

 

Izevbigie, E. B., Gutkind, J.S., and Ray, P.E.  Isoproterenol inhibits basic fibroblast growth factor-induced renal cell proliferation.  Pediatric Neuphrology 14: 726- 734, 2000.