Dr. Paul B. Tchounwou, Sc.D., F.A.B.I., I.O.M. Professor,  Chair and Director Environmental Science Ph.D. Program Tel. (601) 979-3321 Fax. (601) 979-2349 Email: paul.b.tchounwou@jsums.edu Website: ccaix.jsums.edu/~paul.b.tchounwou

Education:

Post-Doc.   Tulane University Medical Center    Molecular Toxicology, 1996.

Sc.D.          Tulane University Medical Center   Environmental Toxicology, 1990.

M.S.P.H.    Tulane University Medical Center   Environmental Health Sciences, 1986.

M.Sc.         University of Yaounde  Biochemistry, 1984.

B.Sc.          University of Yaounde  Biological Sciences, 1983.

Research interests:

Molecular and cellular mechanisms of chemical-induced toxicity; environmental mutagenicity and carcinogenicity; chemical modulation of cell cycle progression; biomarkers of exposure, sensitivity and effect; chemical-induced apoptosis and necrosis; environmental pathology and health risk assessment; environmental epidemiology and public health; QSAR, toxicokinetics and environmental modeling.

Recent Publications: (2000-2005)

Book

Tchounwou PB, and Yu H (Editors). Recent Advances in Environmental Health Research: Health Disparities, Toxicology, and Carcinogenesis. ISBN 3-906980-12-X. Molecular Diversity Preservation International. Basel, Switzerland. 2003, 341 pages.

Recent Publications

• Chigbu P, Gordon S, and Tchounwou PB. The Seasonality of Fecal Coliform Bacteria Pollution and its Influence on Closures of Shellfish Harvesting Areas in Mississippi Sound. International Journal of Environmental Research and Public Health. 2(2), 362-373, 2005.

• Glass KY, Newsome CR, and Tchounwou PB. Cytotoxicity and Expression of c-fos, HSP70, and GADD45/153 Proteins in Human Liver Carcinoma (HepG₂) Cells Exposed to Dinitrotoluenes. International Journal of Environmental Research and Public Health. 2(2), 355-361, 2005.

• Hill DD, Owens WE and Tchounwou PB. Impact of Animal Waste Application on Runoff Water Quality in Field Experimental Plots. International Journal of Environmental Research and Public Health. 2(2), 314-321, 2005.

• Ishague AB, Timmons C, Ballard FV, Hupke C, Dulal K, Johnson LR, Gerald TM, Boucaud D, and Tcounwou PB. Cytotoxicity of Dinitrotoluenes (2.4-DNT, 2,6-DNT) to MCF-7 and MRC-5 Cells. International Journal of Environmental Research and Public Health. 2(2), 304-307, 2005.

• Patlolla B, Patlolla AK, and Tcounwou PB. Cytogenetic Effects of 1,1-Dichloroethane in Mice Bone Marrow Cells. International Journal of Environmental Research and Public Health. 2(1), 101-106, 2005

• Hill DD, Owens WE and Tchounwou PB. Comparative Assessment of the Physico-Chemical and Bacteriological Qualities of Selected Streams in Louisiana. International Journal of Environmental Research and Public Health. 2(1), 94-100, 2005.

• Hill DD, Owens WE and Tchounwou PB. Prevalence of Selected Bacterial Infections Associated with the Use of Animal Waste in Louisiana. International Journal of Environmental Research and Public Health. 2(1), 84-93, 2005.

• Patlolla AK, and Tcounwou PB. Serum Acetyl Cholinesterase as a Biomarker of Arsenic Induced Neurotoxicity in Sprague-Dawley Rats. International Journal of Environmental Research and Public Health. 2(1), 80-83, 2005.

• Dorsey WC, Ford BD, Roane L, Haynie DT, and Tchounwou PB. Induced Mitogenic Activity in AML-12 Mouse Hepatocytes Exposed to Low-dose Ultra-Wideband Electromagnetic Radiation. International Journal of Environmental Research and Public Health. 2(1), 24-30, 2005.

• Graham-Evans B, Colhy HHP, Yu H, and Tchounwou PB.  Arsenic-induced genotoxic and cytotoxic effects in human keratinocytes, melanocytes, and dendritic cells. International Journal of Environmental Research and Public Health. 1(2), 83-89, 2004.

• Dorsey WC, Tchounwou PB, and Sutton DJ.  Mitogenic and cytotoxic effects of pentachlorophenol to AML 12 mouse hepatocytes. International Journal of Environmental Research and Public Health. 1(2), 100-105, 2004.

• Dorsey WC, and Tchounwou PB.  Pentachlorophenol-induced cytotoxic, mitogenic, and endocrine-disrupting activities in channel catfish, Ictalurus punctatus. International Journal of Environmental Research and Public Health. 1(2), 90-99, 2004.

• Monkiedje A, Njine T, Meyabene-Elono AL, Zebaze SH, Kemka N, Tchounwou PB, and Djomo JE.  Freshwater microcosms-based assessment of ecotoxicological effects of a chemical effluent from the Pilcam industry in Cameroon. International Journal of Environmental Research and Public Health. 1(2), 111-123, 2004.

• Tchounwou PB, and Ayensu W.  Health risk assessment and management of mercury poisoning. Metal Ions in Biology and Medicine, 8, 8-13, 2004.

• Tchounwou PB, and Sutton DJ.  Mercury-induced externalization of phosphatidylserine in human liver carcinoma cells Metal Ions in Biology and Medicine, 8, 123-126, 2004.

• Tchounwou PB, Patlolla AK and Centeno JA.  Serum aminotransferases as biomarkers of arsenic-induced hepatotoxicity. Metal Ions in Biology and Medicine, 8, 284-288, 2004.

• Centeno JA, Tchounwou PB, Patlolla AK, Mullick FG, Murakat L, Meza E, Gibb H, Longfellow D, and Yedjou CG. Environmental pathology and health effects of arsenic poisoning: a critical review. In: Naidu R, Smith E, Smith J and Bhattacharya P eds. Managing Arsenic In the Environment: From Soil to Human Health. CSIRO Publishing Corp. Adelaide, Australia. (Book Chapter in Press), 2004.

• Centeno JA, Mullick FG, Tchounwou PB, Franks TJ, Koss MN, Sabnis S, Perl DP, Burke AP, and Ishak KG. Environmental pathology and medical geology. In: Selinius O eds. Medical Geology. Uppsala, Sweden. (Book Chapter in Press), 2004.

• Forawi HA, Tchounwou PB, and McMurray RW. Xenoestrogen Modulation of the Immune System: Effects of DDT and TCDD. Reviews on Environmental Health 19(1): 1-13, 2004.

• Tchounwou PB, Centeno JA and Patlolla AK.  Health risk assessment and management of arsenic toxicity and carcinogenesis. Metal Ions in Biology and Medicine, 8: 14-18, 2004.

• Tchounwou PB. Environmental research and public health –editorial. International Journal of Environmental Research and Public Health, 1(1): 1-2, 2004.

• Ndebele K, Tchounwou PB, and McMurray R. Coumestrol, biphenyl-A, DDT, and TCDD modulation of interleukin-2 expression in activated CD+4 Jurkat T cells. International Journal of Environmental Research and Public Health, 1(1): 3-11, 2004.

• Washington T and  Tchounwou PB. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells exposed to iprodione. International Journal of Environmental Research and Public Health, 1(1): 12-20, 2004.

• Ayensu W, Tchounwou PB, and McMurray R. Molecular and cellular mechanisms associated with autoimmune diseases. International Journal of Environmental Research and Public Health, 1(1): 39-74, 2004.

• Tchounwou PB, Centeno JA and Patlolla AK. Arsenic toxicity, mutagenesis and carcinogenesis - a health risk assessment and management approach. Molecular and Cellular Biochemistry 255: 47-55, 2004.

• Tchounwou PB, Yedjou CG, Foxx D, Ishaque A and Shen E. Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2).  Molecular and Cellular Biochemistry 255: 161-170, 2004.

• Ishaque AB, Tchounwou PB, Wilson BA and Washington T. Developmental arrest in Japanese medaka (Oryzias latipes) embryos exposed to sublethal concentrations of atrazine and arsenic trioxide. Journal of Environmental Biology 25(1), 1-6, 2004.

• Tchounwou PB, Newsome C, Glass K, Centeno JA, Leszczynski J, Bryant J, Okoh J, Ishaque AB, Brower M. Environmental toxicology and health effects associated with dinitrotoluene  exposure. Reviews on Environmental Health 18(3), 203-2229, 2003.

• Tchounwou PB, Yedjou CG, and Dorsey WC. Arsenic-trioxide-induced transcriptional activation of stress genes and expression of related proteins in  human liver carcinoma cells (HepG2).  Cellular and Molecular Biology 49(7): 1070-1079, 2003.

• Tchounwou PB, Ayensu W, Nanashvili N, and Sutton D. Environmental exposure to mercury and its toxico-pathological implications for public health. Environmental Toxicology 18: 149-175, 2003.

• Tchounwou PB, Patlolla AK, and Centeno JA. Carcinogenic and systemic health effects associated with arsenic exposure - a critical review. Toxicologic Pathology 31: 1-14, 2003.

• Waneene CD, and Tchounwou PB. CYP1A1, HSP70, p53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol. Biomedical Sciences Instrumentation, 389-396, 2003.

• Ndebele K, Tchounwou PB, and McMurray R. Effects of xenoestrogens on T lymphocytes: Modulation of bcl2, p53, and apoptosis. International Journal of Molecular Sciences, 4(1-2): 13-21, 2003.

• Graham-Evans B, Tchounwou PB, and Cohly HP. Cytotoxicity and proliferation studies with arsenic in established human cell lines: keratinocytes, melanocytes, dendritic cells, dermal fibroblasts, microvascular endothelial cells, monocytes, and T-cells. International Journal of Molecular Sciences, 4(1-2): 13-21, 2003.

• Tchounwou PB, Ashour BA, Moreland-Young C, Ragheb DA, Romeh AA, Goma EA, El-Sheikh S, Lidell FP, Ibitayo O, and Assad JC. Health risk assessment of pesticide usage in Menia El-Kamh province of Sharkia Governorate in Egypt. International Journal of Molecular Sciences, 3(10): 1082-1094, 2002.

• Tchounwou PB, Wilson BA, Abdelghani AA, Ishaque AB, Patlolla AK. Differential cytotoxicity and gene expression in human liver carcinoma cells exposed to arsenic trioxide, and monosodium acid methylarsonate. International Journal of Molecular Sciences, 3(10): 1117-1132, 2002.

• Dorsey WC, Tchounwou PB, Ishaque AB, and Shen E. Transcriptional activation of stress genes and cytotoxicity in human liver carcinoma cells exposed to pentachlorophenol. International Journal of Molecular Sciences, 3(9): 992-1007, 2002.

• Sutton D, Tchounwou PB, Ninashvili N, and Shen E.  Mercury induces cytotoxicity, and transcriptionally activates stress genes in human liver carcinoma cells. International Journal of Molecular Sciences, 3(9): 965-984, 2002.

• Tchounwou PB, and Yu H. Editorial on the Special Issue on Recent Advances in Environmental Health Research: Health Disparities, Toxicology and Carcinogenesis. International Journal of Molecular Sciences, 3(9): 931-933, 2002.

• Spencer H, Hussein W, and Tchounwou PB. Effects of tetrachloroethylene on the viability and development of embryos of the Japanese medaka, Oryzias latipes. Archives of Environmental Contamination and Toxicology 42:463-469, 2002.

• Tchounwou PB, Ishaque A, Sutton D, Ninashvili N, and Shen E. Biomarkers of sensitivity and effects associated with cadmium and mercury toxicity in human liver carcinoma cells. In: Khassanova L, Collery Ph, Maymard I, Khassanova Z, and Etienne H, Eds. Metal Ions in Biology and Medicine, 7:132-137, 2002.

• Tchounwou PB. Health risk assessment and management of arsenic toxicity and carcinogenesis. In: Khassanova L, Collery Ph, Maymard I, Khassanova Z, and Etienne H, Eds. Metal Ions in Biology and Medicine, 7:365-370, 2002.

• Tchounwou PB, and Warren M. Bacteriological evaluation of water quality in the Ross Barnett Reservoir in Mississippi. Reviews on Environmental Health 16(3): 49-59, 2001.

• Tchounwou PB, Ishaque A and Schneider J. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2) exposed to cadmium chloride.  Molecular and Cellular Biochemistry 222: 21-28, 2001.

• Tchounwou PB, Wilson B, Ishaque A and Schneider J. Atrazine Potentiation od arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2).  Molecular and Cellular Biochemistry 222: 49-59, 2001.

• Tchounwou PB, Wilson B, Ishaque A and Schneider J. Transcriptional activation of stress genes, and  Cytotoxicity in human liver carcinoma cells (HepG2) exposed to 2,4,6-Trinitrotoluene, 2,4-Dinitrotoluene, and 2,6-Dinitrotoluene. Environmental Toxicology-An International Journal 16: 209-216, 2001.

• Tchounwou PB, Wilson B, and Ishaque A. Embryotoxicity of arsenic trioxide, and atrazine to Japanese medaka (Oryzias latipes), and cytotoxicity to human liver carcinoma cells (HepG2).

• Book Chapter in: Environmental Toxicology and Risk Assessment: Science Policy and Standardization-Implications for Environmental Decisions: Tenth Volume, BM Greenberg, RN Hull, MH Roberts, and RW Gensemer, Eds. American Society for Testing and Materials. West Conshohocken, Pennsylvania.  ASTM STP 1403: 83-95, 2001.

• Tchounwou PB, and Reed L. Applications of Microbial Bioassays in the Assessment of Metal Toxicity. Bioremediation, Education Science and Technology Program. 2000 Annual Report to the U.S. Department of the Army. 2000. On line at: http://www-esd.lbl.gov/CEB/BEST/ ann_rpt99/ Eco_2story.hml

• Tchounwou PB, Wilson B, and Ishaque A. Toxicity and Risk Assessment of 2,4,6-Trinitrotoluene, 2,4-Dinitrotoluene, and 2,6-Dinitrotoluene. Bioremediation, Education Science and Technology Program. 2000 Annual Report to the U.S. Department of the Army. 2000. On line at: http://www-esd.lbl.gov/CEB/BEST/ann_rpt99/Eco_3story.hml

• Tchounwou PB, Wilson B, and Ishaque A, Ransome R., Huang MJ, and Leszczynski J. Toxicity assessment of atrazine and related triazine compounds in the Microtox assay, and computational modeling for their structure-activity relationship. International Journal of Molecular Sciences 1:63-74, 2000.

• Tchounwou PB. Climate change and its potential impacts on the Gulf Coast region of the United States. In: Ning ZH, and Abdollahi KK, Eds. Current Stresses and Potential Vulnerabilities-Implications of Global Change for the Gulf Coast Region of the United States. GCRCCC and Franklin Press Inc., Baton Rouge, LA. pp. 18-22, 2000.

• Tchounwou PB, and Reed L. Effects of cadmium and lead on the bioluminescence of Vibrio fischeri, and the growth and oxygen uptake of microorganisms. In: Centeno JA, Collery Ph, Vernet G. Finkelman RB, Gibb H, and Etienne H, Eds. Metal Ions in Biology and Medicine, 6:682-684, 2000.

•  Tchounwou PB, Wilson B, Schneider J, and Ishaque A. Cytogenetic assessment of arsenic trioxide toxicity in the Mutatox, Ames II, and CAT-Tox (L) assays. In: Centeno JA, Collery Ph, Vernet G. Finkelman RB, Gibb H, and Etienne H, Eds. Metal Ions in Biology and Medicine, 6:89-91, 2000.

• Tchounwou PB. Health risk assessment and management of arsenic and other toxic and hazardous metals in drinking water.In: Centeno JA, Collery Ph, Vernet G. Finkelman RB, Gibb H, and Etienne H, Eds. Metal Ions in Biology and Medicine, 6:22-23, 2000.

• Tchounwou PB, Wilson B, Ishaque A, and Sutton D. Toxicity evaluation of arsenic trioxide and atrazine to three developmental stages of Japanese medaka (Oryzias latipes). In: Centeno JA, Collery Ph, Vernet G. Finkelman RB, Gibb H, and Etienne H, Eds. Metal Ions in Biology and Medicine, 6:18-21, 2000.

• Tchounwou PB, Siddig AA, and Marian ML. Post-remediation  monitoring for soil, sediment and water contamination by lead from a controlled Superfund site in Mississippi, USA. In: Environmental Toxicology and Risk Assessment: Eighth Volume, ASTM STP 1381. F.T. Price, K.V. Brix, and N.K. Lane, Eds. American Society for Testing and Materials, West Conshohocken, PA. pp. 16-32. 2000.