Education: Tougaloo College , Chemistry, B.S. University of Southern Mississippi , Chemistry, Ph.D My research interest is in the area of environmental genome. There has been an increase occurrence of cancer, asthma, eczema, etc. in the United States over the last several decades, which has led many scientists to speculate about an environmental component to various diseases. Our research focus is on the investigation of how these environmental agents affect the function, mutation, and repair mechanism of DNA with possible correlations to environmentally induced chronic disease. DNA stores genetic information and any alteration or mutation that occurs in the DNA sequence can change its function or the function of its gene product and alter the susceptibility to diseases. DNA has the ability to react with various chemical compounds including agents found in the environment. These agents can modify and damage the DNA strands. If the damaged DNA is not correctly repaired by cellular mechanisms, it could lead to mutations, which may contribute to disease. Our current research project examines the effect of a common ionic liquid series, imidazolium salt, on DNA function and repair. Publications: X. A. Gibson, A. Shartava, J. McIntyre, C. Monteiro, Y. Zhang, A. Shah, N. F. Campbell , and S. R. Goodman. 1998 . The Efficacy of reducing agents or antioxidants in blocking the formation of irreversibly sickled cells in vitro . Blood 91: 4373-4378. N. F. Campbell, L. E. Jones, R. S. Mazenko, and M. B. Medina. 1997 . Development of a chromatographic method for the isolation and detection of hygromycin B in biological fluids. J. Chrom B: Biomed. Appl. 692: 367-374. N. F. Campbell, F. F. Shih, J. S. Hamada, and W. E. Marshall. 1996 . Effect of limited proteolysis on the enzymatic phosphorylation of soy protein . J. Agric. Food Chem. 44: 759-762.
|
