{"id":1031,"date":"2013-05-21T19:23:33","date_gmt":"2013-05-21T19:23:33","guid":{"rendered":"https:\/\/www.jsums.edu\/chemistry\/?page_id=1031"},"modified":"2017-04-10T16:27:57","modified_gmt":"2017-04-10T16:27:57","slug":"ashton-t-hamme-ii","status":"publish","type":"page","link":"https:\/\/www.jsums.edu\/chemistry\/ashton-t-hamme-ii\/","title":{"rendered":"Ashton T. Hamme II"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n
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\n\t\t\t\t\tProfessor & Interim Chair<\/b><\/i><\/strong>
\n\t\t\t\t<\/h4>\n<\/td>\n<\/tr>\n

\n\t\t\t\t \"hamme2\"<\/a>\n\t\t\t<\/td>\n\n

\n\t\t\t\t\tP<\/i><\/b><\/span>hysical location:<\/i><\/b><\/span>\n\t\t\t\t<\/p>\n

\n\t\t\t\t\tJohn A. Peoples Science Building
\n\t\t\t\t\tOffice: room #539\n\t\t\t\t<\/p>\n

\n\t\t\t\t\tContact:<\/span><\/i><\/b>
\n\t\t\t\t\tE-mail: ashton.t.hamme@jsums.edu<\/a>
\n\t\t\t\t\tTel: (601) 979-2171
\n\t\t\t\t\tFax: (601) 979-3674\n\t\t\t\t<\/p>\n

\n\t\t\t\t\tHamme Research Group<\/span><\/b>\n\t\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t\t\tTeaching<\/b><\/span>
\n\t\t\t\t<\/h4>\n<\/td>\n<\/tr>\n

\n\t\t\t\tOrganic Chemistry Part I CHEM 241
\n\t\t\t\tOrganic Chemistry Part II CHEM 242
\n\t\t\t\tOrganic Chemistry Laboratory Part I CHML 241
\n\t\t\t\tOrganic Chemistry Laboratory Part II CHML 242
\n\t\t\t\tAdvanced Organic Synthesis CHEM 738\n\t\t\t<\/td>\n<\/tr>\n
\n

\n\t\t\t\t\t
\n\t\t\t\t\tResearch Interests: <\/b><\/span>
\n\t\t\t\t<\/h4>\n<\/td>\n<\/tr>\n

\n\t\t\t\tThe Hamme research group is interested in the synthesis of biologically active heterocyclic containing natural products and their synthetic analogues.  Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system.  Our research group is also interested in the use of pure water as a reaction medium for organic synthesis.    <\/strong>\n\t\t\t<\/td>\n<\/tr>\n
\n

\n\t\t\t\t\t
\n\t\t\t\t\tSelected publications<\/span> (Click here for full list<\/a>)<\/b>
\n\t\t\t\t<\/h4>\n<\/td>\n<\/tr>\n

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    \n
  1. \n\t\t\t\t\t\tS Dadiboyena, AT Hamme, One pot spiropyrazoline synthesis via intramolecular cyclization\/methylation, Tetrahedron letters 52 (20), 2536-2539, 2011<\/strong>.\n\t\t\t\t\t<\/li>\n
  2. \n\t\t\t\t\t\tDadiboyena, S.; Valente, E. J.; Hamme, A. T. II “Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates” Tetrahedron Lett. <\/i>2010<\/b>, 51<\/i>, 1341-1343.\n\t\t\t\t\t<\/li>\n
  3. \n\t\t\t\t\t\tEllis, E. D.; Xu, J.; Valente, E. J.; Hamme, A. T. II “Construction of Novel Spiroisoxazolines via Intramolecular Cyclization\/Methylation” Tetrahedron Lett.<\/i> 2009<\/b>, 50<\/i>, 5516-5519.\n\t\t\t\t\t<\/li>\n
  4. \n\t\t\t\t\t\tMcClendon, E.; Omollo, A. O.; Valente, E. J.; Hamme, A. T. II “Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines” Tetrahedron Lett.<\/i> 2009<\/b>, 50<\/i>, 533-535.\n\t\t\t\t\t<\/li>\n
  5. \n\t\t\t\t\t\tDadiboyena, S.; Valente, E. J.; Hamme, A. T. II “A Novel Synthesis of 1,3,5-Trisubstituted Pyrazoles through a Spiro-pyrazoline Intermediate via a Tandem 1,3-Dipolar Cycloaddition\/Elimination” Tetrahedron Lett.<\/i> 2009, <\/b>50<\/i>, 291-294.<\/i>\n\t\t\t\t\t<\/li>\n
  6. \n\t\t\t\t\t\tXu, J.; Hamme, A. T. II “Efficient Access to Isoxazoles from Alkenes” Synlett<\/i> 2008<\/b>, 919-923.\n\t\t\t\t\t<\/li>\n
  7. \n\t\t\t\t\t\tRasulev, B. F.; Toropov, A. A.; Hamme, A. T. II; Leszczynski, Jerzy.  “Multiple linear regression analysis and optimal descriptors: predicting the Cholesteryl Ester Transfer Protein inhibition activity” QSAR & Combinatorial Science 2008<\/b>, 27<\/i>, 595-606.\n\t\t\t\t\t<\/li>\n
  8. \n\t\t\t\t\t\tDadiboyena, S.; Xu, J.; Hamme, A. T. II “Isoxazoles from 1,1-Disubstituted Bromoalkenes” Tetrahedron Lett.<\/i> 2007<\/b>, <\/b>48<\/i>, 1295-1298.\n\t\t\t\t\t<\/li>\n
  9. \n\t\t\t\t\t\tXu, J.; Wang, J.; Ellis, E. D.; Hamme, A. T. II “Spiroisoxazoline Synthesis via Intramolecular Cyclization\/Methylation” Synthesis<\/i> 2006<\/b>, 3815-3818.\n\t\t\t\t\t<\/li>\n
  10. \n\t\t\t\t\t\tSong, Y.; Xu, J.; Hamme, A.; Liu, Y-M. “Capillary Liquid Chromatography-Tandem Mass Spectrometry of Tetrahydroisoquinoline Derived Neurotoxins:  Study on the Blood-Brain Barrier of Rat Brain” J. Chromatogr. A<\/i> 2006<\/b>, 1103<\/i>, 229.\n\t\t\t\t\t<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

    Professor & Interim Chair   Physical location: John A. Peoples Science Building Office: room #539 Contact: E-mail: ashton.t.hamme@jsums.edu Tel: (601) 979-2171 Fax: (601) 979-3674 Hamme Research Group Teaching Organic Chemistry Part I CHEM 241 Organic Chemistry Part II CHEM 242 Organic Chemistry Laboratory Part I CHML 241 Organic Chemistry Laboratory Part II CHML 242 Advanced […]<\/p>\n","protected":false},"author":32,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1031"}],"collection":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=1031"}],"version-history":[{"count":21,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1031\/revisions"}],"predecessor-version":[{"id":1754,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1031\/revisions\/1754"}],"wp:attachment":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=1031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}