{"id":1187,"date":"2013-05-24T22:08:52","date_gmt":"2013-05-24T22:08:52","guid":{"rendered":"https:\/\/www.jsums.edu\/chemistry\/?page_id=1187"},"modified":"2022-07-19T20:23:34","modified_gmt":"2022-07-19T20:23:34","slug":"ogunge","status":"publish","type":"page","link":"https:\/\/www.jsums.edu\/chemistry\/ogunge\/","title":{"rendered":"Ifedayo Victor Ogungbe"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n
\n

\u00a0Associate Professor<\/b><\/h4>\n<\/td>\n<\/tr>\n

\"IVO\"<\/a>1400 J. R. Lynch Street, P.O. Box 17910<\/span>
\nJackson, MS 39217-0510<\/span>Physical location:<\/i><\/b>John A. Peoples Science Building<\/span>: Room #510<\/span><\/p>\n
Contact:<\/i><\/b><\/h5>\n

E-mail:\u00a0ifedayo.v.ogungbe@jsums.edu<\/a>
\nTel: (601) 979-3719
\nFax: (601) 979-3674<\/td>\n<\/tr>\n

\n

Teaching<\/b><\/span><\/h4>\n<\/td>\n<\/tr>\n

Organic Chemistry, Biochemistry, Physical Organic Chemistry<\/td>\n<\/tr>\n
\n

Research Interests:\u00a0<\/span><\/b> <\/i><\/h4>\n<\/td>\n<\/tr>\n

Characterization and biological activity of small molecules, Molecular recognition and interactions, Bioinspired design. We use computational chemistry, structural biology, organic synthesis, as well as biochemical (in vitro<\/i> and in vivo<\/i>) tools and assays to study how bioactive compounds and\/or their mimetic interact with\u00a0molecular targets. \u00a0We hope that the knowledge generated from our work will help in the development of new therapies and materials.\u00a0LINK<\/a><\/td>\n<\/tr>\n
\n

Selected publications<\/span> (Click here for full list)<\/b><\/h4>\n<\/td>\n<\/tr>\n

\n
1. Nyamwihura RJ, Ogungbe IV. The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance. RSC advances. 2022, 12, 11346-11375.<\/span><\/div>\n
2. Nyamwihura RJ, Zhang H, Collins JT, Crown O, Ogungbe IV. Nopol-Based Quinoline Derivatives as Antiplasmodial Agents. Molecules. 2021, 26: 1008.\u00a0 PMC7917639<\/span><\/div>\n
3. Santos CC, Zhang H, Batista MM, de Oliveira GM, Demarque KC, da Silva-Gomes NL, Moreira OC, Ogungbe IV, Soeiro MD. In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis. Antimicrobial agents and chemotherapy. 2020, 64: e01188-20.\u00a0<\/span><\/div>\n
4. Zhang H, Harmon M, Radoshitzky Sheli, Soloveva V, Kane Chris, Duplantier Allen, Ogungbe, IV. Vinyl Sulfone-Based Inhibitors of Non-Structural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus. ACS Med. Chem. Letters, 2020, 11, 2139\u20132145<\/span><\/div>\n
5. Zhang H, Collins J, Nyamwihura R, Crown O, Ajayi O, Ogungbe IV. Vinyl Sulfone-based Inhibitors of Trypanosomal Cysteine Protease Rhodesain with Improved Antitrypanosomal Activities. Bioorganic & Medicinal Chemistry Letters. 2020, 127217.<\/span><\/div>\n
6. Zhang H, Collins J, Nyamwihura R, Ware S, Kaiser M, Ogungbe IV. Discovery of a Quinoline-Based Phenyl Sulfone Derivative as an Antitrypanosomal Agent. Bioorganic and Medicinal Chemistry Letters 2018, 28: 1647-1651. PMC5912169<\/span><\/div>\n
7. Byler KG, Collins JT, Ogungbe IV, Setzer WN. Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation. Comput Biol Chem. 2016, 64:163-184. PMID: 27387412.<\/span><\/div>\n
8. Jefferson T, McShan D, Warfield J, Ogungbe IV. Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity. Chemical Biology & Drug Design 2016, 58: 154-158. PMC4715686<\/span><\/div>\n
9. McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorganic & Medicinal Chemistry Letters 2015, 25: 4509-4512. PMC4592840<\/span><\/div>\n
10. Kaul TK, Reis Rodrigues P, Ogungbe IV, Kapahi P, Gill MS. Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans. PLoS One. 2014: 9(1):e86979. PMCID: PMC3901721<\/span><\/div>\n
<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0Associate Professor 1400 J. R. Lynch Street, P.O. Box 17910 Jackson, MS 39217-0510Physical location:John A. Peoples Science Building: Room #510 Contact: E-mail:\u00a0ifedayo.v.ogungbe@jsums.edu Tel: (601) 979-3719 Fax: (601) 979-3674 Teaching Organic Chemistry, Biochemistry, Physical Organic Chemistry Research Interests:\u00a0 Characterization and biological activity of small molecules, Molecular recognition and interactions, Bioinspired design. We use computational chemistry, structural […]<\/p>\n","protected":false},"author":32,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1187"}],"collection":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=1187"}],"version-history":[{"count":6,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1187\/revisions"}],"predecessor-version":[{"id":1832,"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/pages\/1187\/revisions\/1832"}],"wp:attachment":[{"href":"https:\/\/www.jsums.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=1187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}