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Ashton T. Hamme II

Professor & Interim Chair


Physical location:

John A. Peoples Science Building
Office: room #539

Tel: (601) 979-2171
Fax: (601) 979-3674

Hamme Research Group


Organic Chemistry Part I CHEM 241
Organic Chemistry Part II CHEM 242
Organic Chemistry Laboratory Part I CHML 241
Organic Chemistry Laboratory Part II CHML 242
Advanced Organic Synthesis CHEM 738

Research Interests:

The Hamme research group is interested in the synthesis of biologically active heterocyclic containing natural products and their synthetic analogues.  Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system.  Our research group is also interested in the use of pure water as a reaction medium for organic synthesis.    

Selected publications (Click here for full list)

  1. S Dadiboyena, AT Hamme, One pot spiropyrazoline synthesis via intramolecular cyclization/methylation, Tetrahedron letters 52 (20), 2536-2539, 2011.
  2. Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates” Tetrahedron Lett. 2010, 51, 1341-1343.
  3. Ellis, E. D.; Xu, J.; Valente, E. J.; Hamme, A. T. II “Construction of Novel Spiroisoxazolines via Intramolecular Cyclization/Methylation” Tetrahedron Lett. 2009, 50, 5516-5519.
  4. McClendon, E.; Omollo, A. O.; Valente, E. J.; Hamme, A. T. II “Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines” Tetrahedron Lett. 2009, 50, 533-535.
  5. Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “A Novel Synthesis of 1,3,5-Trisubstituted Pyrazoles through a Spiro-pyrazoline Intermediate via a Tandem 1,3-Dipolar Cycloaddition/Elimination” Tetrahedron Lett. 2009, 50, 291-294.
  6. Xu, J.; Hamme, A. T. II “Efficient Access to Isoxazoles from Alkenes” Synlett 2008, 919-923.
  7. Rasulev, B. F.; Toropov, A. A.; Hamme, A. T. II; Leszczynski, Jerzy.  “Multiple linear regression analysis and optimal descriptors: predicting the Cholesteryl Ester Transfer Protein inhibition activity” QSAR & Combinatorial Science 2008, 27, 595-606.
  8. Dadiboyena, S.; Xu, J.; Hamme, A. T. II “Isoxazoles from 1,1-Disubstituted Bromoalkenes” Tetrahedron Lett. 2007, 48, 1295-1298.
  9. Xu, J.; Wang, J.; Ellis, E. D.; Hamme, A. T. II “Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation” Synthesis 2006, 3815-3818.
  10. Song, Y.; Xu, J.; Hamme, A.; Liu, Y-M. “Capillary Liquid Chromatography-Tandem Mass Spectrometry of Tetrahydroisoquinoline Derived Neurotoxins:  Study on the Blood-Brain Barrier of Rat Brain” J. Chromatogr. A 2006, 1103, 229.