Associate Professor
Jackson State University
Department of Chemistry and Biochemistry
1400 J. R. Lynch Street
P.O. Box 17910
Jackson, MS 39217-0510
Physical location:
John A. Peoples Science Building
Office: room #539
Contact:
E-mail: ashton.t.hamme@jsums.edu
Tel: (601) 979-3713
Fax: (601) 979-3674
Hamme Research Group
Teaching
Organic Chemistry Part I CHEM 241
Organic Chemistry Part II CHEM 242
Organic Chemistry Laboratory Part I CHML 241
Organic Chemistry Laboratory Part II CHML 242
Advanced Organic Synthesis CHEM 738
Research Interests: Organic chemistry
The Hamme research group is interested in the synthesis of biologically active heterocyclic containing natural products and their synthetic analogues. Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system. Our research group is also interested in the use of pure water as a reaction medium for organic synthesis.
Selected publications
Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates” Tetrahedron Lett. 2010, 51, 1341-1343.
Ellis, E. D.; Xu, J.; Valente, E. J.; Hamme, A. T. II “Construction of Novel Spiroisoxazolines via Intramolecular Cyclization/Methylation” Tetrahedron Lett. 2009, 50, 5516-5519.
McClendon, E.; Omollo, A. O.; Valente, E. J.; Hamme, A. T. II “Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines” Tetrahedron Lett. 2009, 50, 533-535.
Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “A Novel Synthesis of 1,3,5-Trisubstituted Pyrazoles through a Spiro-pyrazoline Intermediate via a Tandem 1,3-Dipolar Cycloaddition/Elimination” Tetrahedron Lett. 2009, 50, 291-294.
Xu, J.; Hamme, A. T. II “Efficient Access to Isoxazoles from Alkenes” Synlett 2008, 919-923.
Rasulev, B. F.; Toropov, A. A.; Hamme, A. T. II; Leszczynski, Jerzy. “Multiple linear regression analysis and optimal descriptors: predicting the Cholesteryl Ester Transfer Protein inhibition activity” QSAR & Combinatorial Science 2008, 27, 595-606.
Dadiboyena, S.; Xu, J.; Hamme, A. T. II “Isoxazoles from 1,1-Disubstituted Bromoalkenes” Tetrahedron Lett. 2007, 48, 1295-1298.
Xu, J.; Wang, J.; Ellis, E. D.; Hamme, A. T. II “Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation” Synthesis 2006, 3815-3818.
Song, Y.; Xu, J.; Hamme, A.; Liu, Y-M. “Capillary Liquid Chromatography-Tandem Mass Spectrometry of Tetrahydroisoquinoline Derived Neurotoxins: Study on the Blood-Brain Barrier of Rat Brain” J. Chromatogr. A 2006, 1103, 229.
Hamme, A. T. II; Xu, J.; Wang, J.; Cook, T.; Ellis, E. “Synthesis of Functionalized 5,5-Disubstituted Isoxazolines via 1,3-Dipolar Cycloaddition Reactions of Geminal Disubstituted Alkenes” Heterocycles 2005, 65, 2885-2892.