Ifedayo Victor Ogungbe

 Assistant Professor

IVO1400 J. R. Lynch Street, P.O. Box 17910
Jackson, MS 39217-0510

Physical location:

John A. Peoples Science Building: Room #528B

Contact:

E-mail: ifedayo.v.ogungbe@jsums.edu
Tel: (601) 979-3719
Fax: (601) 979-3674

Teaching

Organic Chemistry, Qualitative Organic Analysis, Physical Organic Chemistry

Research Interests: 

Characterization and biological activity of small molecules, Molecular recognition and interactions, Bioinspired design. We use computational chemistry, structural biology, organic synthesis, as well as biochemical (in vitro and in vivo) tools and assays to study how bioactive compounds and/or their mimetic interact with molecular targets.  We hope that the knowledge generated from our work will help in the development of new therapies and materials. LINK


Selected publications (Click here for full list)

  1. Jefferson T, McShan D, Warfield J, Ogungbe IV. Screening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal Activity. Chemical Biology & Drug Design (2016). 87(1):154-8.
  2. McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorganic & Medicinal Chemistry Letters (2015), 25(20):4509-12.
  3. Harrison N, Lone MA, Kaul TK, Reis Rodrigues P, Ogungbe IV, Gill MS. Characterization of N-Acyl Phosphatidylethanolamine-Specific Phospholipase-D Isoforms in the Nematode Caenorhabditis elegans. PLoS One. 2014; 9(11):e113007.
  4. Ogungbe IV, Crouch RA, Demeritte T. (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. J Chem Inf Model. 2014; 54(11):3051-5. doi: 10.1021/ci500537e. 
  5. Kaul TK, Reis Rodrigues P, Ogungbe IV, Kapahi P, Gill MS. Bacterial fatty acids enhance recovery from the dauer larva in Caenorhabditis elegans. PLoS One.  2014; 9(1):e86979.
  6. Ogungbe IV, Erwin WR, Setzer WN. Antileishmanial phytochemical phenolics: molecular docking to potential protein targets. J Mol Graph Model. 2014; 48:105-17.
  7. Ogungbe IV, Ng JD, Setzer WN. Interactions of antiparasitic alkaloids with Leishmania protein targets: a molecular docking analysis. Future Med Chem. 2013; 5(15):1777-99.
  8. Ogungbe IV, Setzer WN. In-silico Leishmania target selectivity of antiparasitic terpenoids. Molecules. 2013 Jul 3;18(7):7761-847. doi: 10.3390/molecules18077761.
  9. Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, et al. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases – part II. Current Medicinal Chemistry. 2012; 19(14):2176-228.
  10. Ogungbe IV, Hill GM, Crouch RA, Vogler B, Nagarkoti M, Haber WA, Setzer WN. Prenylated isoflavonoids from Rhynchosia edulis. Nat Prod Commun. 2011; 6(11):1637-44.